1st Faculty of Medicine Charles University 1st Faculty of Medicine Charles University Institute of Immunology and Microbiology


Bobek J. (2016) Novel bioactive compounds produced by Actinomycetales through the mixed cultivation techniques (pdf)

Cihak M. (Master student) (2016) midterm report on sec. metabolism during germination [in Czech] (pdf)

Setinova D. (PhD student) (2016) asRNAs manuscript to be submitted (pdf)

Smidova K. (PhD student) (2016) submitted SigQ manuscript (pdf)

Setinova D, Novotna K, Vohradsky J, Bobek J. (2015) Cis-antisense RNAs in Streptomyces, to be submitted (pdf)

Bobek J, Strakova E, Zikova A, Vohradsky J., (2014) Changes in activity of metabolic and regulatory pathways during germination of S. coelicolor. BMC Genomics. 15:1-15. (http://www.ncbi.nlm.nih.gov/pubmed/25539760)

Mikulík K, Bobek J, Zídková J, Felsberg J. (2014) 6S RNA modulates growth and antibiotic production in Streptomyces coelicolor. Appl Microbiol Biotechnol. 98(16): 7185-7197. (http://www.ncbi.nlm.nih.gov/pubmed/24859522)

Strakova E, Bobek J, Zikova A, Vohradsky J. (2013) Global features of gene expression on the proteome and transcriptome levels in S. coelicolor during germination. PLoS One. 8(9): 1-14. (http://www.ncbi.nlm.nih.gov/pubmed/24039809)

Strakova E, Bobek J, Zikova A, Rehulka P, Benada O, Rehulkova H, Kofronova O, Vohradsky J. (2013) Systems insight into the spore germination of Streptomyces coelicolor. J Proteome Res. 12(1): 525-536. (http://www.ncbi.nlm.nih.gov/pubmed/23181467)

Mikulik K, Felsberg J, Kudrnáčová E, Bezoušková S, Setinová D, Stodůlková E, Zídková J, Zídek V. (2012) CobB1 deacetylase activity in Streptomyces coelicolor. Biochem Cell Biol. 90(2):179-187. (

Pánek J, Krásny L, Bobek J, Jezková E, Korelusová J, Vohradsky J. (2011) The suboptimal structures find the optimal RNAs: homology search for bacterial non-coding RNAs using suboptimal RNA structures. Nucleic Acids Res. 39(8): 3418-3426. (http://www.ncbi.nlm.nih.gov/pubmed/21193488)

Mikulík K, Bobek J, Ziková A, Smětáková M, Bezoušková S. (2011) Phosphorylation of ribosomal proteins influences subunit association and translation of poly (U) in Streptomyces coelicolor. Mol Biosyst. 7(3): 817-823. (http://www.ncbi.nlm.nih.gov/pubmed/21152561)

Palecková P, Bobek J, Mikulík K. (2009) tmRNA of Streptomyces collinus and Streptomyces griseus during the growth and in the presence of antibiotics. Microb Biotechnol. 2(1): 114-122. (http://www.ncbi.nlm.nih.gov/pubmed/21261886)

Swiercz JP, Hindra, Bobek J, Haiser HJ, Di Berardo C, Tjaden B, Elliot MA. (2008) Small non-coding RNAs in Streptomyces coelicolor. Nucleic acids Res. 36(22): 7240-7251. (http://www.ncbi.nlm.nih.gov/pubmed/19008244)

Pánek J, Bobek J, Mikulík K, Basler M, Vohradský J. (2008) Biocomputational prediction of small non-coding RNAs in Streptomyces. BMC Genomics. 9(217): 1-11. (http://www.ncbi.nlm.nih.gov/pubmed/18477385)

Mikulík K, Palecková P, Felsberg J, Bobek J, Zídková J, Halada P. (2008) SsrA genes of streptomycetes and association of proteins to the tmRNA during development and cellular differentiation. Proteomics. 8(7): 1429-1441. (http://www.ncbi.nlm.nih.gov/pubmed/18306177)

Palecková P, Felsberg J, Bobek J, Mikulík K. (2007) tmRNA abundance in Streptomyces aureofaciens, S. griseus and S. collinus under stress-inducing conditions. Folia Microbiol (Praha). 52(5): 463-470. (http://www.ncbi.nlm.nih.gov/pubmed/18298042)

Palecková P, Kontrová F, Kofronová O, Bobek J, Benada O, Mikulík K. (2007) Effect of protein kinase inhibitors on protein phosphorylation and germination of aerial spores from Streptomyces coelicolor. Folia Microbiol (Praha). 52(3): 215-222. (http://www.ncbi.nlm.nih.gov/pubmed/17702458)

Palecková P, Bobek J, Felsberg J, Mikulík K. (2006) Activity of translation system and abundance of tmRNA during development of Streptomyces aureofaciens producing tetracycline. Folia Microbiol (Praha). 51(6): 517-524. (http://www.ncbi.nlm.nih.gov/pubmed/17455787)

Bobek J, Halada P, Angelis J, Vohradský J, Mikulík K. (2004) Activation and expression of proteins during synchronous germination of aerial spores of Streptomyces granaticolor. Proteomics. 4(12): 3864-3880. (http://www.ncbi.nlm.nih.gov/pubmed/15378695)

Mikulík K, Bobek J, Bezousková S, Benada O, Kofronová O. (2002) Expression of proteins and protein kinase activity during germination of aerial spores of Streptomyces granaticolor. Biochem Biophys Res Commun. 299(2): 335-342. (http://www.ncbi.nlm.nih.gov/pubmed/12437991)

Mikulík K, Suchan P, Bobek J. (2001) Changes in ribosome function induced by protein kinase associated with ribosomes of Streptomyces collinus producing kirromycin. Biochem Biophys Res Commun. 289(2): 434-443. (http://www.ncbi.nlm.nih.gov/pubmed/11716492)

Bobek J, Hercík K, Dobrová Z, Branny P, Nádvorník R, Janecek J. (2000) Evidence for phosphoprotein phosphatase in Streptomyces granaticolor. Folia Microbiol (Praha). 45(4): 310-312. (http://www.ncbi.nlm.nih.gov/pubmed/11347251)

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